Basic Molecular Biology

Molecular biology reveals the gene structure and function, which also provides us powerful tools to explore the mystery of life science.

开设学校：西安交通大学；学科：理学、

Basic Molecular Biology 课程：前往报名学习

Basic Molecular Biology 视频慕课课程简介：

Molecular biology reveals the gene structure and function, which also provides us powerful tools to explore the mystery of life science.

前往报名学习

Basic Molecular Biology 课程列表：

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Chapter 1 The material basis of genetic information

- C1-Lecture 1 The past and present journey of molecular biology

--Key points C1-L1 The past and present journey of molecular biology

--Video-C1-L1 The past and present journey of molecular biology

--Discussion C1-L1

--Lecture 1-Homework

-C1-Lecture 2 The nature of genetic material

--Key points C1-L2 The nature of genetic material

--Video-C1-L2 The nature of genetic material

--Discussion C1-L2

--C1-Lecture 2-Homework

-C1-Lecture 3 Amazing DNA double helix

--Key points C1-L3 Amazing DNA double helix

--Video C1-L3 Amazing DNA double helix

--Discussion C1-L3

--C1-Lecture 3-Homework

-C1-Lecture 4 Supercoiled DNA

--Key points C1-L4 Supercoiled DNA

--Video C1-L4 Supercoiled DNA

--Discussion C1-L4

--C1-Lecture 4-Homework

-C1-Lecture 5 Denaturation, renaturation and hybridization

--Key points C1-L5 Denaturation, renaturation and hybridization

--Video C1-L5 Denaturation, renaturation and hybridization

--Discussion C1-L5

--C1-Lecture 5-Homework

-C1-Lecture 6 Nucleic acids extraction and gel electrophoresis

--Key points C1-L6 Nucleic acid extraction and gel electrophoresis

--Video C1-L6 Nucleic acid extraction and gel electrophoresis

--Discussion C1-L6

--C1-Lecture 6-Homework

-Chapter 1 Test

-Learning resources

--Web resources

-- References

Chapter 2 From gene to chromosome

-C2-Lecture 1 Genome does not equal to chromosome

--Key points C2-L1 Genomes are not equal to chromosomes

--Video C2-L1 Genomes are not equal to chromosomes

--Discussion C2-L1 Genomes are not equal to chromosomes

--C2-Lecture 1-Homework

-C2-Lecture 2 Nucleosomes and their Assembly

--Key points C2-L2 Nucleosomes and their Assembly

--Video C2-L2 Nucleosomes and their Assembly

--Discussion C2-L2 Nucleosomes and their Assembly

--C2-Lecture 2-Homework

-C2-Lecture 3 Higher order chromatin structure

--Key points C2-L3 Higher order chromatin structure

--Video C2-L3 Higher order chromatin structure

--Discussion C2-L3 Higher order chromatin structure

--C2-Lecture 3-Homework

-C2-Lecture 4 Chromatin modification and remodeling

--Key points C2-L4 Chromatin modification and remodeling

--Video C2-L4 Chromatin modification and remodeling

--Discussion C2-L4 Chromatin modification and remodeling

--C2-Lecture 4-Homework

-Chapter 2 Tests

-Learning resources

--Web resources

--References

Chapter 3 Who is in pairs? DNA replication

-C3-Lecture 1 Semiconservative DNA replication

--Key points C3-L1 Semiconservative DNA replication

--Video C3-L1 Semiconservative DNA replication

--Discussion C3-L1 Semiconservative DNA replication

--C3-Lecture1 Homework

-C3-Lecture 2 The mechanism of DNA polymerase

--Key points C3-L2 The mechanism of DNA polymerase

--Video C3-L2 The mechanism of DNA polymerase

--Discussion C3-L2 The mechanism of DNA polymerase

--C3-Lecture 2-Homework

-C3-Lecture 3 Process of DNA replication

--Key points C3-L3 Process of DNA replication

--Video C3-L3 Process of DNA replication

--Discussion C3-L3 Process of DNA replication

--C3-Lecture 3-Homework

-C3-Lecture 4 Regulation of DNA replication initiation

--Key points C3-L4 Regulation of DNA replication initiation

--Video C3-L4 Regulation of DNA replication initiation

--Discussion C3-L4 Regulation of DNA replication initiation

--C3-Lecture 4-Homework

-C3-Lecture 5 The end replication problem and telomere

--Key points C3-L5 The end replication problem and telomere

--Video C3-L5 The end replication problem and telomere

--Discussion C3-L5 The end replication problem and telomere

--C3-Lecture 5-Homework

-C3-Lecture 6 Let’s “cook” DNA

--Video C3-L6 Let’s “cook” DNA

--Discussion C3-L6 Let’s “cook” DNA

--C3-Lecture 6-Homework

- Chapter 3 Tests

-Learning resources

--Web resources

--References

Chapter 4 DNA mutation and repair

-C4-Lecture 1 Replication errors and the mismatch repair system

--Key points 4-1 Replication errors and the mismatch repair system

--Video 4-1 Replication errors and the mismatch repair system

--Discussion 4-1 Replication errors and the mismatch repair system

--C4-Lecture 1-Homework

-C4-Lecture 2 DNA damage

--Key points 4-2 DNA damage

--Video 4-2 DNA damage

--Discussion 4-2 DNA damage

--C4-Lecture 2-Homework

-C4-Lecture 3 DNA Repair

--Key points 4-3 DNA Repair

--Video 4-3 DNA Repair

--Discussion 4-3 DNA Repair

--C4-Lecture 3-Homework

-C4-Lecture 4 DNA Homologous Recombination

--Key points 4-4 DNA Homologous Recombination

--Video 4-4 DNA Homologous Recombination

--Discussion 4-4 DNA Homologous Recombination

--C4-Lecture 4-Homework

-C4-Lecture 5 Changing the natural gene sequences

--Key points 4-5 Changing the natural gene sequences

--Video 4-5 Changing the natural gene sequences

--Discussion 4-5 Changing the natural gene sequences

-Chapter 4 test

- Learning resources

--Web resources

--References

--References

Chapter 5 Transcription in prokaryotes

-C5-Lecture 1 RNA polymerase

--Key points 5-1 RNA polymerase

--Video 5-1 RNA polymerase

--Discussion 5-1 RNA polymerase

--C5-Lecture 1-Homework

-C5-Lecture 2 Transcription process in prokaryotes

--Key points 5-2 Transcription process in prokaryotes

--Video 5-2 Transcription process in prokaryotes

--Discussion 5-2 Transcription process in prokaryotes

--C5-Lecture 2-Homework

-C5-Lecture 3 Transcriptional regulation in bacterial I: Lac operon

--Key points 5-3 Transcriptional regulation in bacterial I: Lac operon

--Video 5-3 Transcriptional regulation in bacterial I: Lac operon

--Discussion 5-3 Transcriptional regulation in bacterial I: Lac operon

--C5-Lecture 3-Homework

-C5-Lecture 4 Transcriptional regulation in bacterial II: Tryptophan operon

--Key points 5-4 Transcriptional regulation in bacterial II: Tryptophan operon

--Video 5-4 Transcriptional regulation in bacterial II: Tryptophan operon

--Discussion 5-4 Transcriptional regulation in bacterial II: Tryptophan operon

--C5-Lecture 4-Homework

-Chapter 5 Test

-Learning resources

--References

Chapter 6 Transcription in eukaryotes

-Lecture 1 Eukaryotic RNA polymerase and promoter

--Key points 6-1 Eukaryotic RNA polymerase and promoter

--Video 6-1 Eukaryotic RNA polymerase and promoter

--Discussion 6-1 Eukaryotic RNA polymerase and promoter

--C6-Lecture 1-Homework

-Lecture 2 Transcription process in eukaryotic cell

--Key points 6-2 Transcription process in eukaryotic cell

--Video 6-2 Transcription process in eukaryotic cell

--Discussion 6-2 Transcription process in eukaryotic cell

--C6-Lecture 2-Homework

-Lecture 3 Transcription factors of eukaryotic cell

--Key points 6-3 Transcription factors of eukaryotic cell

--Video 6-3 Transcription factors of eukaryotic cell

--Discussion 6-3 Transcription factors of eukaryotic cell

--C6-Lecture 3-Homework

-Lecture 4 Epigenetic Regulation of gene expression

--Key points 6-4 Epigenetic Regulation of gene expression

--Video 6-4 Epigenetic Regulation of gene expression

--Discussion 6-4 Epigenetic Regulation of gene expression

--C6-Lecture 4-Homework

-Chapter 6 Test

-Learning resources

--Web resources

--References

Chapter 7 RNA Processing

-Lecture 1 RNA splicing

--Key points 7-1 RNA splicing

--Video 7-1 RNA splicing

--Discussion 7-1 RNA splicing

--C7-Lecutre 1-Homework

-Lecture 2 Cotranscriptional processing of nuclear pre-mRNA

--Key points 7-2 Cotranscriptional processing of nuclear pre-mRNA

--Video 7-2 Cotranscriptional processing of nuclear pre-mRNA

--Discussion 7-2 Cotranscriptional processing of nuclear pre-mRNA

--C7-Lecture 2-Homework

-Lecture 3 One gene one protein? Alternative RNA splicing

--Key points 7-3 One gene one protein? Alternative RNA splicing

--Video 7-3 One gene one protein? Alternative RNA splicing

--Discussion 7-3 One gene one protein? Alternative RNA splicing

--C7-Lecture 3-Homework

-Lecture 4 “Seeing” RNA

--Key points 7-4 “Seeing” RNA

--Video 7-4 “Seeing” RNA

--Discussion 7-4 “Seeing” RNA

-C7-Lecture 4-Homework

-Chapter 7 Test

-Learning Resources

--References

Chapter 8 Protein Synthesis, translation

-Lecture 1 Genetic codons and ribosome

--Key points 8-1 Genetic codons and ribosome

--Video 8-1 Genetic codons and ribosome

--Discussion 8-1 Genetic codons and ribosome

--C8-Lecture 1-Homework

-Lecture 2 Process of translation

--Key points 8-2 Process of translation

--Video 8-2 Process of translation

--Discussion 8-2 Process of translation

--C8-Lecture 2-Homework

-Lecture 3 Regulation of gene expression at Translational level

--Key points 8-3 Regulation of gene expression at Translational level

--Video 8-3 Regulation of gene expression at Translational level

--Discussion 8-3 Regulation of gene expression at Translational level

--C8-Lecture 3-Homework

-Lecture 4 Looking for your protein

--Key points 8-4 Looking for your protein

--Video 8-4 Looking for your protein

-Chapter 8 Test

-Learning resources

--References

--Life Cycle of an mRNA

--mRNA procesiing

--Protein synthesis

--SDS-PAGE

Final Exam

-Final Exam

Basic Molecular Biology 开设学校：西安交通大学

Basic Molecular Biology 授课教师：

卢晓云-教授-西安交通大学-

博士，教授，博导。2000年于北京大学医学部获得学士学位、2005年于清华大学生命科学院获博士学位。2008-2010年在意大利都灵大学医学院分子生物技术中心从事博士后研究工作。承担西安交通大学生命学院本科生《分子生物学》（双语课）和《分子细胞生物学》等课程，课堂教学深受同学喜爱。获得亚洲与大洋洲生物化学与分子生物学家联合会教育奖，负责国家精品在线开放课程《分子生物学——原理与技术》。先后获得西安交通大学教师授课竞赛双语组一等奖，王宽诚育才奖和西安交通大学“教书育人”先进个人等称号，并先后在中国生物化学与分子生物学会微课竞赛和全国高校教师微课竞赛中获奖。主要从事聚羟基脂肪酸酯的生物医药应用及电磁生物学研究。主持国家级科研项目7项，省部级科研项目2项，发表期刊学术论文SCI收录的学术论文50余篇，获国家授权发明专利一项。

闫菡-讲师-西安交通大学-

博士，讲师。1995年于西北大学获学士学位、2003年于西安交通大学获硕士学位、2010年于西安交通大学获博士学位。2006年-2007年在美国密苏里大学堪萨斯城分校医学院访问交流。长期从事本科生教学工作，主讲普通生物学、生物学基础Fundamental Biology、生命科学基础I、生命科学基础II、遗传学Genetics、生物（少年班）、分子生物学实验等。2013年荣获西安交通大学授课竞赛三等奖、2019年荣获西安交通大学授课竞赛一等奖。普通生物学课程在学生评教中连续5年均获评优秀。主要从事复杂疾病的分子遗传学与基因组学的研究，主持国家自然科学基金1项，陕西省科技项目1项，发表期刊学术论文13篇（SCI收录12篇）。

冯怡-副教授-西安交通大学-

冯怡，博士，副教授，博导，斯坦福大学访问学者。2010年3月至今就职于西安交通大学生物医学工程系，承担西安交通大学生物医学工程系本科生《分子生物学》（双语），《生物化学》和《分子细胞生物学》、西安交通大学全校本科生《生命科学基础II》和生物医学工程系研究生英文专业课《Functional and Molecular Imaging》的教学工作，教学效果广受好评。主要从事生物医学超声诊疗及其生物学效应研究，主持国家自然科学基金2项，省部级自然科学基金2项。参与国家973计划，国科金重点项目和国家科研仪器专项等3项。发表学术论文20多篇，作为副主编出版英文专著1本，中文专著1本，参编中文教材两本。

谭丹-副教授-西安交通大学-

谭丹，清华大学理学博士，西安交通大学生命学院副教授，美国加州大学洛杉矶分校（UCLA）访问学者。《基因工程》，《合成生物学》主讲教师，合作发表教改论文2篇，参与申请西安交通大学教改项目1项，参编科学出版社“十三五”规划教材《分子细胞生物学》，参与国家精品慕课《分子生物学-原理与技术》课程辅助教学工作。主持包括国家重点研发计划“合成生物学专项”子课题在内的国家级、省部级等多个项目，发表论文十余篇。

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