当前课程知识点:Pathology > Chapter4 Partial blood circulation disorders > Section1 Partial blood circulation disorders > Partial blood circulation disorders
Hello everyone
My name is Liu Yang I'm the teacher in this chapter of partial blood circulation disorders
Then in the this chapter
We will study few knowledge points
Firstly relative to local disturbance of blood circulation
There is systemic disturbance of blood circulation
They are closely related
The systemic disturbance of blood circulation
showed heart failure
It could cause organs or tissues
showed corresponding disturbance of blood circulation
The blood circulation disorders in coronary arteries
as a local disturbance of blood circulation
In turn it could cause heart failure
Which will affect systemic blood circulation disorders
So they are closely related
In this chapter we will focus on
some points
The first one is the change of blood
The second one is the change in blood flow
The third one is the change of blood quality
Finally we will introduce
some changes in the blood vessel wall
including the increased permeability
and the rupture of blood vessel walls
causing the ruptured bleeding
The first point is Hyperemia
Hyperemia is in the blood vessels of local tissues and organs
Increased blood content
It showed arterial hyperemia and venous hyperemia
Venous hyperemia is also called congestion
The common types of arterial hyperemia
included physiological hyperemia inflammatory hyperemia
and hyperemia after decompression
For example
the hyperemia in the stomach after we eat or exercise
and the muscle hyperemia
all of them are the physiological hyperemia
Then in terms of pathological changes of arterial congestion
It mainly comes down to three words
they are big red and hot
Large means
A slight increase in the volume of tissues and organs
Red means local oxygen and hemoglobin increase
and it showed red
Hot means that this local metabolic energy increases
which increased heat production
It will showed three outcomes
Firstly after removing the cause
it could be completely recovered
Secondly on the basis of hypertension or arteriosclerosis
it occurred arterial hyperemia
It is easy to cause a breaking bleeding
Thirdly the hyperemia after decompression
At this time the brain tissue obtained decreased blood
It is easy to cause collapse or syncope
Then the reasons of venous congestion
is the obstruction in venous reflux actually
So the blood accumulates in small arteries and veins
or in the capillaries
There are three main reasons
Three reasons are internal resistance external pressure and heart failure
As for the pathological manifestations
there are three main points
They are large purple and cold
Large means a slight increase in the volume of tissues and organs
Purple refers to the increase of reduced hemoglobin
and veins located below the body surface
so it is easy to cause heat dissipation increasing
Then they caused
purple and cold
Under the microscope
it showed dilation of small veins and capillaries
and contained lots of red blood cells
Hyperemia could also be caused by a permeability change of the blood vessel wall
accompanying with edema or hyperemia
The outcomes of venous hyperemia
has three main points
Firstly it could be recovered after the cause is removed
The second one is that it will cause congestive sclerosis after long-term congestion
The last one is when the permeability of the blood vessel wall increased
it will cause leaky haemorrhage
We have two examples
They are chronic liver congestion and chronic lung congestion
Let's look at chronic liver congestion first
The reasons caused chronic liver congestion
are similar to the reasons of chronic lung congestion
The main reason causing liver congestion is right heart failure
while the lung congestion due to the left heart failure
So let's study the pathological manifestations of the lung congestion
It showed as an increasing in lung volume
the section showed the dark red
and pink foamy liquid
There are four important features under the microscope
The first one is the thickening of the blood vessel wall
and the capillary vessel showed expansion
The second one is the change in alveolar cavity
They have large amounts of protein edema fluid red blood cells
Another one is a typical diagnostic heart failure cells
The heart failure cells arises in the left heart failure
In the process of chronic lung congestion
Macrophages phagocytosis with hemosiderin appeared in the alveolar cavity
We named it heart failure cells
Please see the image
It showed the general appearance of chronic lung congestion
It showed an increase in size
Mild congestion and red appearance
This is a normal lung tissue
The alveolar interval is relatively thin
Gas exchange in alveolar cavity
This is the microscopic histological image of chronic lung congestion
The alveolar interval in the image is wide
There are a lot of edema fluid in the alveolar cavity
In the alveolar cavity
as the arrow indicated in this image
There are a lot of hemosiderin in the heart failure cells
when we diagnosed chronic lung congestion
This image showed the same content
What about the outcome of chronic pulmonary congestion?
The patient always has a wheezing and difficulty breathing
or cough with pink foamy sputum
so the patient will get pulmonary sclerosis after long-term process of chronic pulmonary congestion
As for the chronic liver congestion
The right heart failure caused to blocked return of vena cava causes
then lead to the congestion of the liver
In terms of pathological changes
we use nutmeg liver to describe its general performance
It has the surface with red and yellow
There is a congestion around the central vein under the microscope
Hepatocytes atrophy
The hepatocyte around liver lobule showed fatty degeneration
Its clinical manifestations are mainly tenderness in the liver area
and decreasing in liver function
In B-ultrasound or other auxiliary examinations
You could see a slight increase in the liver
Its outcome is congestive cirrhosis arising from long-term chronic liver congestion
This is its typical rough image
We can see that its section is red and yellow
We call it nutmeg liver
This is the corresponding normal liver image
The hepatic cord and sinuses present the radial arrangement around the central vein
This is a normal histological structure
As for the change of blood volume
The last point is bleeding
Bleeding is caused by the escape of blood from the blood vessels or from the heart
It can be divided into physiological or pathological according to whether there is disease
it can be divided into ruptured and leaking according to the spillover mechanism
it can be divided into internal bleeding or external bleeding according to the location of bleeding
Ruptured bleeding is the most common type of bleeding
The main reason is mechanical damage
the heart or the walls of blood vessels
The most common feature is aneurysm rupture
The other reasons included tuberculosis malignant tumor ulcer
These are caused by erosion of blood vessels
Just like variceal bleeding
The varicose veins of the blood vessels appeared in the cirrhosis of the liver
For example in the varices at the lower part of esophagus
Then it showed variceal bleeding
It is more common that
Such as capillaries rupture in some soft tissue contusions
Then in this image
There is a bleeding spot on the surface of the intestinal mucosa
It's a encephalocoele hemorrhage
That's the end of this chapter
Thank you
-Section1 Introduction to pathology
-Section2 The position of pathology in medicine
--The position of pathology in medicine
-Section3 How to learn pathology well
-Exercises
-PPT
-Section1 Adaptation of Cells and Tissues
--Adaptation of Cells and Tissues
-Section2 Cause and mechanism of injury
--Cause and mechanism of injury
-Section3 Degeneration
-Section4 Necrosis
--Necrosis
-Section5 Apoptosis
-Exercises
-PPT
-Exercises
-PPT
-Section1 Partial blood circulation disorders
--Partial blood circulation disorders
-Section2 Thrombosis
-Section3 Embolism
--Embolism
-Section4 Infarction
-Exercises
-PPT
-Section1 Summary
--Summary
-Section2 Acute inflammation
-Section3 Types of acute inflammation
-Section4 Chronic inflammation
-Section5 Local manifestations and systemic reactions of inflammation
--Local manifestations and systemic reactions of inflammation
-Section6 The process and outcome of inflammation
--The process and outcome of inflammation
-Section1 Neoplasm
--Neoplasm