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Helicobacter pylori causes peptic ulcer课程教案、知识点、字幕

幽门螺旋杆菌

引起消化性溃疡

又称慢性消化性溃疡

主要病变在十二指肠

或者是胃

十二指肠溃疡多见 占70%

而胃溃疡发病 占25%

两者同时发生为复合性溃疡 占5%

我们这里讲的

消化性溃疡

不仅仅指这个溃疡

发生在消化系统

而是指的这个溃疡的发生

与胃的消化有关

所以把它称为 消化性溃疡

消化性溃疡的病因和发病机制

我们可以把消化性溃疡的发病

分解为三个方面

也就是病因学上的致病三角

一 是致溃疡力增强

二 是抗溃疡力下降

三 是影响致溃疡力增强和

或者抗溃疡力下降的因素

构成三个方面

什么是致溃疡力和抗溃疡力

致溃疡力就是胃的消化作用

包括胃酸和胃蛋白酶

在正常的情况下

胃液为什么不会

对自身组织进行消化

因为胃粘膜具有抗消化保护作用

也就是抗溃疡力

抗溃疡力

主要由胃粘膜屏障功能

包括胃粘膜被覆上皮细胞

之间的紧密连接

胃粘膜上皮被覆一层厚厚的粘液

所形成的粘液屏障

而前列腺素

对胃粘膜的保护作用

被称为功能性屏障

前列腺素对胃粘膜的保护作用

是通过增加胃粘膜的血流

来抵抗胃酸中的氢离子

对胃粘膜的逆弥散而实现的

既保持正常的消化

又能抵抗溃疡发生

一旦这个平衡打破

导致致溃疡力增强或者和

抗溃疡力下降

消化性溃疡就可以发生

影响致溃疡力增强或

和抗溃疡力下降的因素

一 幽门螺旋杆菌感染

是最重要的因素

幽门螺旋杆菌感染

既可以使致溃疡力增强

又可以使抗溃疡力下降

幽门螺旋杆菌感染

有诱使胃酸分泌

而本身又不惧怕胃酸的杀菌作用

幽门螺旋杆菌感染

寄生于胃粘膜小凹

破坏胃粘膜被覆上皮细胞

之间的紧密连接

同时又削弱胃粘膜粘液的

屏障功能

就像造成屋漏一样

这就是屋漏学说

二 长期服用非类固醇类抗炎药

阻断前列腺素合成

削弱前列腺素的功能性屏障

而使抗溃疡力下降

三 长期精神紧张

促使胃酸分泌增加

致使致溃疡力增加

四 吸烟 长期吸烟 把烟雾吞入

造成胃粘膜损伤

致使抗溃疡力下降

五 高钙血症

促使胃酸分泌增加

六 胃泌素瘤

胃蛋白酶分泌增加

致使致溃疡力增加

七 胆汁返流

致使胃酸分泌增加

又由于胆汁当中的

牛磺胆酸钠有清除粘液

消弱粘液屏障的功能

Gateway to Medicine: An Introduction to the Field of Medicine课程列表:

CH01 Smog and Lung Diseases

-01-The basic condition of the air

--The basic condition of the air

-02-What is smog and its influence to the body

--What is smog and its influence to the body

-03-The structure and the function of human respiratory system

--The structure and the function of human respiratory system

-04-How the smog cause the human respiratory system disease

--How the smog cause the human respiratory system disease

-05-Asthma

--Asthma

-Exercise 01

-06-COPD

--COPD

-07-Lung cancer Ⅰ

--Lung cancer Ⅰ

-08-Lung cancer Ⅱ

--Lung cancer Ⅱ

-Exercise 02

CH02 Pregnancy and Delivery

-01 Dissection of genital organs

--Dissection of genital organs

-Exercise 01

-02 The formation of embryo and fetal appendage

--The formation of embryo and fetal appendage

-Exercise 02

-03 Characteristic of embryonic and fetal development

--Characteristic of embryonic and fetal development

-04 Maternal changes during pregnancy

--Maternal changes during pregnancy

-05 Four factors that affect childbirth

--Four factors that affect childbirth

-06 Mechanism of labor

--Mechanism of labor

CH03 Children’s nutrition requirement and infant feeding

-01 The energy requirement and the metabolic characteristics of kids

--The energy requirement and the metabolic characteristics of kids

-02 Need of the nutrition and metabolism of kids Ⅰ

--Need of the nutrition and metabolism of kids Ⅰ

-Exercise 01

-03 Need of the nutrition and metabolism of kids Ⅱ

--Need of the nutrition and metabolism of kids Ⅱ

-Exercise 02

-04 Guided feeding of infant Ⅰ

--Guided feeding of infant Ⅰ

-Exercise 03

-05 Guided feeding of infant Ⅱ

--Guided feeding of infant Ⅱ

-06 Guided feeding of infant Ⅲ

--Guided feeding of infant Ⅲ

CH04 Get to know about tumor

-01 Introduction

--Introduction

-02 What is tumor

--What is tumor

-03 The general shape of tumor

--The general shape of tumor

-04 The atypia of the tumor

--The atypia of the tumor

-05 Name and classification of the tumor

--Name and classification of the tumor

-Exercise 01

-06 The growing type of the tumor

--The growing type of the tumor

-07 Spread of tumor

--Spread of tumor

-Exercise 02

-08 The grading and staging of tumors and the effects to the body

--The grading and staging of tumors and the effects to the body

-09 The difference between benign and malignant tumors

--The difference between benign and malignant tumors

-10 The environmental causes of cancer

--The environmental causes of cancer

-11 Heredity and tumor

--Heredity and tumor

CH05 Emergency (Cardiopulmonary resuscitation) and Disaster Medicine

-01 Overview

--Overview

-02 Sudden cardiac arrest

--Sudden cardiac arrest

-Exercise 01

-03 Non-professional life support

--Non-professional life support

-Exercise 02

-04 Professional life support

--Professional life support

-Exercise 03

-05 Adult advanced life support Ⅰ

--Adult advanced life support Ⅰ

-Exercise 04

-06 Adult advanced life support Ⅱ

--Adult advanced life support Ⅱ

-Exercise 05

-07 Electric defibrillation

--Electric defibrillation

CH06 Cardiovascular disease (Atherosclerosis and hypertension)

-01 Introduction

--Introduction

-02 Risk factors and pathogenesis of atherosclerosis

--Risk factors and pathogenesis of atherosclerosis

-03 Pathological changes of atherosclerosis

--Pathological changes of atherosclerosis

-Exercise 01

-04 Atherosclerosis of vital organs

--Atherosclerosis of vital organs

-05 Coronary atherosclerotic heart disease

--Coronary atherosclerotic heart disease

-Tips 03

--Tips 03

-06 Primary hypertension

--Primary hypertension

-Exercise 02

-07 The etiology and pathogenesis of hypertension

--The etiology and pathogenesis of hypertension

-08 The types and pathologic changes of essential hypertension

--The types and pathologic changes of essential hypertension

-Exercise 03

CH07 The war that never ends——Human versus virus

-01 Overview Ⅰ

--Overview Ⅰ

-02 Overview Ⅱ

--Overview Ⅱ

-03 What is virus

--What is virus

-Exercise 01

-04 The structure and functions of influenza viruses

--The structure and functions of influenza viruses

-Exercise 02

-05 Different type of influenza viruses

--Different type of influenza viruses

-Exercise 03

-06 Bird flu

--Bird flu

-Exercise 04

-07 Street virus

--Street virus

-Exercie 05

CH08 The germs that gastric acid can't kill——Helicobacter pylori and Gastric diseases

-01 Introduction

--Introduction

-02 Chronic gastritis caused by helicobacter pylori infection

--Chronic gastritis caused by helicobacter pylori infection

-Exercise 01

-03 Helicobacter pylori causes peptic ulcer

--Helicobacter pylori causes peptic ulcer

-Exercise 02

-04 Pathological changes of peptic ulcer

--Pathological changes of peptic ulcer

-Exercise 03

-05 Gastric cancer

--Gastric cancer

CH09 The movement and injury of human body——The motor function of human body

-01 The evolution of biological motion

--The evolution of biological motion

-02 Biomechanics of human motion

--Biomechanics of human motion

-Exercise 01

-03 The perfect unity of function and structure

--The perfect unity of function and structure

-Exercise 02

-04 A brief history of trauma orthopedic development Ⅰ

--A brief history of trauma orthopedic development Ⅰ

-05 A brief history of trauma orthopedic development Ⅱ

--A brief history of trauma orthopedic development Ⅱ

-Exercise 03

-06 Sprain and fracture of the ankle joint

--Sprain and fracture of the ankle joint

-Exercise 04

-07 Ankle sprain

--Ankle sprain

-Exercise 05

-08 Prevention of ankle sprain

--Prevention of ankle sprain

Final Exam

-Final Exam

Helicobacter pylori causes peptic ulcer笔记与讨论

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